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Materials and methods br Results br Discussion Microbial pro
2020-10-19
Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino trilithium for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the existin
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br Conflicts of interest br
2020-10-19
Conflicts of interest Acknowledgements This study was funded by Kuwait University Research Administration (Project MI03/10). Introduction Epidemiological, experimental and biologic plausibility support a cardioprotective effect of estrogens in women [1]. Indeed, women are protected until t
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Introduction Taenia solium is the causative agent of
2020-10-19
Introduction Taenia solium is the causative agent of human taeniasis/cysticercosis and porcine cysticercosis, a major health problem and a veterinary economic challenge in developing countries of Latin America, Africa, and Asia. In Mexico, approximately 500 human neurocysticercosis cases were repor
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It is reported that sympathetic nerve activity
2020-10-17
It is reported that sympathetic nerve activity is increased in the SHR strain compared with that in the WKY strain (Judy and Farrell, 1979, Lundin et al., 1984, Sugimura et al., 2008) and NA content is increased in the CB of the New Zealand strain of hypertensive rat compared with that in normotensi
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PF 4800567 hydrochloride synthesis DNA hypomethylation has b
2020-10-17
DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, PF 4800567 hydrochloride synthesis tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hyp
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The biological significance of DNA ligases is
2020-10-17
The biological significance of DNA ligases is attributed to their function in DNA replication, recombination and/or DNA repair [1], [2]. In vertebrates, three different DNA ligases I, III and IV are recognized. DNA ligase I is essential for the Okazaki fragments’ ligation during lagging-strand DNA s
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br Compliance with ethical standards This work was
2020-10-17
Compliance with ethical standards This work was conducted in compliance with ethical standards. Conflict of interest Funding The work was funded by extra mural research grant (EMR/2016/005135) from Science and Engineering Research Board, Government of India. Acknowledgements Introduc
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We have reported previously that aminoacrylate derivatives o
2020-10-17
We have reported previously that β-aminoacrylate derivatives of the general structure () are inhibitors of DHODH. In particular, tricyclic derivatives and displayed sub-micromolar IC values against DHODH, and in the case of there was a 1000-fold greater potency compared to the human enzyme (DHOD
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Chlorprothixene Pulmonary fibroblasts can regulate the
2020-10-17
Pulmonary fibroblasts can regulate the wound healing process by secreting and processing extracellular matrix (ECM), chemokines, and cytokines. However, persistent and atypical fibroblast proliferation can result in ECM accumulation and may trigger the onset or development of pulmonary fibrosis [[17
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DBU mg A range of therapies exists for
2020-10-17
A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al., 2008). Despite of these notable successes, there are still major unmet medical needs in the t
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br Expression and Purification of Atg and Atg
2020-10-17
Expression and Purification of Atg4 and Atg8 Proteins for In Vitro Assays Measurement of Atg4 Activity In Vitro and Ex Vivo Kinetics Analysis of Atg4 Enzymes Summary Atg4 proteases play a crucial role in preparing Atg8 for conjugation to lipid membranes and for the deconjugation of Atg8
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Pahlavanzadeh and Fakouri Baygi employed PC
2020-10-17
Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the nuclear receptor of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that the AAD was achieved
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To characterize Ea and S DC AC electrical
2020-10-17
To characterize Ea and γ·S, DC/AC electrical parameters will be determined from MIL standard measurements in a temperature range of −55 to +200°C. It is therefore necessary also to characterize the junction temperatures and hot points by infra-red or electrical method. The accelerated aging, represe
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COMT protein expression was investigated as a
2020-10-17
COMT protein prostaglandin endoperoxide synthase was investigated as a potential mechanism by which tolcapone may differentially affect male and female P and Wistar rats. COMT protein levels in the PFC were lower in P rats compared to Wistars but female P rats expressed greater levels of COMT in the
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CK comprises a family of serine threonine protein kinases
2020-10-16
CK1 comprises a family of serine/threonine protein kinases, that includes different CK1 isoforms namely α, β, δ, ε and γ their various splice variants [56]. It was reported that the pharmacological inhibitor IC261 shows an order of magnitude of higher selectivity for CK1δ or CK1ε isoforms (IC50 of 1
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