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br Signaling of DDR receptor and its regulation Being
2020-02-12
Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation
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The cysteinyl leukotrienes cysLTs LTC LTD
2020-02-12
The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the ef
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STO-609 acetate synthesis Furthermore software engineering p
2020-02-12
Furthermore, software engineering practices are important for addressing productivity problems in scientific software. Even though the speed of the hardware is rapidly increasing, the additional complexity makes it more difficult for scientists to be productive developers. According to Faulk et al.,
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Previous studies have documented that SCFAs may elicit effec
2020-02-12
Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero
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Senexin A synthesis Compounds and possessed relatively low c
2020-02-12
Compounds 11–13 and 15 possessed relatively low clogP values and tended to show relatively weak antagonist activity regardless of their potent EP1 receptor affinity. Compounds 2–4, which were selected based on their potent in vivo antagonist activity, were found to be effective in an animal model.
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br Materials and methods br Results and
2020-02-12
Materials and methods Results and discussion Conclusions Codon-optimized MGSK-Lys-C was expressed at a high level in an optimized expression system as inclusion bodies. The Lys-C activity reached its maximum with about 9340 nkat/Lculture under standard (chemical) refolding conditions. The r
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br EBV Infection Epstein Barr virus
2020-02-11
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A).
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br Asb Proteins and Mitochondrial Function
2020-02-11
Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic marbofloxacin and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate a plethora of p
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E ubiquitin ligases are key players
2020-02-11
E3 ubiquitin ligases are key players in the ubiquitin-proteasome pathway because they catalyse ubiquitination of substrate proteins.39, 40, 41 As important regulators of cellular ubiquitination, E3 ligases are emerging as attractive drug targets, particularly in cancer.42, 43, 44 However, E3 ligases
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br Deubiquitination deubiquitinases and cancer
2020-02-11
Deubiquitination, deubiquitinases and cancer Protein deubiquitination is reverse process of ubiquitination and performed by deubiquitinases or deubiquitinating enzymes (DUBs), which help in removal of ubiquitin from target proteins and involve in ubiquitin maturation, recycling and editing (Pfoh
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An important question is to what extent any differences
2020-02-11
An important question is to what extent any differences in radioligand characteristics may have contributed to discrepancies between studies. Two studies on schizophrenia addressed this question directly by using [11C]SCH 23390 and [11C]NCC 112 in the same individuals, not finding any differences be
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Another important issue in biosensors is to design a
2020-02-11
Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase NSC228155 for hydrolyzing sucrose into glucose, the range of personal glucometer has
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Hepatic steatosis is strongly associated with insulin resist
2020-02-11
Hepatic steatosis is strongly associated with insulin resistance. Numerous studies in humans and animals have shown that insulin-resistant states are often accompanied by hepatic steatosis (Angulo and Lindor, 2001, Marchesini et al., 1999, Marchesini et al., 2005, Petersen and Shulman, 2006, Seppala
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Drug drug interactions are frequently attributed
2020-02-11
Drug-drug interactions are frequently attributed to functional alterations in CYP enzymes, including inhibition and induction (Chen et al., 2014, Wang et al., 2013). Mechanism-based inhibition is an irreversible form of enzyme inhibition and could form a stable inhibitor-enzyme complex, which is tho
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The data presented above clearly indicate an important
2020-02-11
The data presented above clearly indicate an important role of eIF4E for the nucleocytoplasmic transport of the human iNOS mRNA. To analyze the sequence elements of the iNOS mRNA that are important for this eIF4E-mediated transport we performed transient transfection experiments using constructs con
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