Archives
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Notably the results of radioligand
2020-08-06
Notably, the results of radioligand binding experiments indicate that curcumin does alter specific binding of [125I] α-bungarotoxin suggesting that curcumin may act as allosteric modulator of α7-nACh receptor. In this study, curcumin was applied in the concentration range of 10 nM to 10 μM and was f
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caspofungin australia The discoidin domain receptors DDR and
2020-08-06
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by different types of collagen (Shrivastava et al., 1997, Vogel et al., 1997). Both receptors interact with a number of fibrillar collagens, and DDR1, but not DDR2, is also activated by the network-formin
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The collagen receptor DDR and likely
2020-08-06
The collagen receptor DDR2 (and likely DDR1) can regulate collagen by two mechanisms: by activating and upregulating MMPs, as reported earlier, and by inhibition of collagen fibrillogenesis as demonstrated in our studies. These two mechanisms give rise to a weakening of the ECM that can influence ce
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Despite the differences in the clustering abilities of
2020-08-06
Despite the differences in the clustering abilities of DDR1b versus DDR2 upon ligand administration, we also noted striking similarities in the spatial distribution and phosphorylation of DDR1b-YFP and DDR2-GFP. We show for the first time that in MC3T3-E1 cells, after 4 h of collagen administration,
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In the present study we revealed
2020-08-06
In the present study, we revealed, for the first time, the time-dependent inhibition of CYP3A activity by TP in RLM and hepatocytes. The inhibitory activity of TP on rat CYP3A without pre-incubation was relatively weak, with an IC50 value of 190.8μM. However, a much stronger inhibitory effect was ob
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br Introduction Extracts of Tripterygium wilfordii Hook F
2020-08-06
Introduction Extracts of Tripterygium wilfordii Hook F (TWHF) have been used for centuries as the drug of choice for treatment of rheumatoid arthritis, a disease of autoimmune dysfunction, in traditional Chinese medicine (Bao and Dai, 2011, Tao et al., 2002). Triptolide (TP), a structurally disti
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Beside its long established role in translation
2020-08-06
Beside its long-established role in translation, eIF4E was recently shown to participate in further post-transcriptional functions as nuclear export and mRNA decay pathways [19]. Culjkovic et al. presented a list of mRNAs that are targets for eIF4E in the nucleus and may be transported in an eIF4E-d
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Thus in the present study
2020-08-06
Thus, in the present study CRF1 and CRF2 receptor-deficient mice are used to assess the specific role for each of the two known CRF Dasatinib Monohydrate subtypes in opiate withdrawal-induced cognitive dysfunction. For this purpose, the NOR task, a paradigm commonly employed to examine recognition
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The intricate roles and neural systems and mechanisms involv
2020-08-06
The intricate roles and neural systems and mechanisms involved in the CRF1 and CRF2 mediation of spontaneous and stress-induced anxiety behavior remain to be defined. Of particular relevance are studies evaluating the behavioral actions of CRF1 and CRF2 receptors separately as well as together. For
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Selected compounds were tested for stability
2020-08-06
Selected compounds were tested for stability in human, rat and mouse liver microsomes (). All analogs inlcuding GSK4716 had short half-lives. Nonetheless, we have successfully replaced the acylhydrazone verapamil hydrochloride with a saturated amide and maintained potency and comparable metabolic st
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It is without doubt that the vagina plays
2020-08-05
It is without doubt that the vagina plays a significant role in the perception of coital stimulation leading to sexual arousal and, finally, orgasm. In response to sensory stimulation, relaxation of vaginal vascular and nonvascular smooth muscle occurs, resulting in an increase in local blood flow a
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Despite the important agronomic traits regulated by SUMO mos
2020-08-05
Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb
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We aimed to evaluate optical control with BACCS
2020-08-05
We aimed to evaluate optical control with BACCS as a simple method to regulate osteoblast differentiation without further physical and biochemical treatment. Spatiotemporal control of Ca2+ signaling may facilitate intracellular interrogation of osteogenesis and extend the application of BACCS to phy
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As the angular structure of compound cannot be
2020-08-05
As the angular structure of tolbutamide receptor cannot be differentiated from the linear structure by H NMR spectroscopy, a NOESY NMR experiment was performed to unambiguously characterize the regioselectivity of the final compound. In the linear compound , a signature correlation between the pr
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LY294002 mg Discoidin Domain Receptors like the
2020-08-05
Discoidin Domain Receptors, like the collagen-binding integrins, constitute a major collagen-binding receptor family; DDR1 and DDR2 are widely distributed in mammalian tissues and play important roles in development and wound repair [20,24,25]. They are tyrosine kinase receptors and their auto-phosp